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Top Ten CBD Oils For Epilepsy And Seizure Disorders

In this article, we will present ten of the best CBD oils to potentially help with epilepsy and seizure disorders.

CBD oil first gained worldwide attention through the story of a little girl named Charlotte Figi. Charlotte suffered from Dravet syndrome, a rare form of epilepsy. By the age of five years old she was having up to 300 grand mal seizures a week and her quality of life was diminished entirely. Out of options, her parents administered CBD oil created by the Stanley Brothers in Colorado. Within a week, her seizures had stopped. Charlotte’s story was quickly grabbed by the media and the Stanley brothers named their CBD strain after Charlotte. Today, Charlotte’s Web is one of the most trusted brands in the treatment of seizure disorders. While it is first on our list, it is certainly not the only high-quality CBD oil available for epilepsy. Many other growers have followed suit, creating some of the best oils available in the world.

CBD has been shown in many studies to be potentially useful in relieving the severity and frequency of seizures, particularly in children. After trying dozens of conventional pharmaceuticals, many patients turned to CBD oil as a last resort with astonishing results. Epilepsy is one of the conditions for which there is no shortage of medical evidence available as to the efficacy of CBD. Following the review, you can find more information about CBD and how it may benefit patients with these conditions.

1. Joy Organics

Premium Hemp Tincture

Using hemp grown right here in the US, Joy Organics’ broad-spectrum CBD oil tincture comes in four main flavors: mint, orange, lemon, or unflavored for those who love the natural taste of CBD. This company’s CBD is entirely THC-free and rich in phytocannabinoid hemp oil, aiming to promote all the potential benefits their hemp plants have to offer. There’s 500mg of CBD in each 30mL dropper bottle and lab reports are available on each product page.

Reviews on Joy Organics’ website show that customers tend to primarily enjoy the “Tranquil Mint” for its ability to promote relaxation, but others preferred the citrusy taste of the lemon-flavored oil. While consumers had many good things to say about the tincture itself, there were equally as many praises about Joy Organics’ customer service, which offers free shipping on all orders and a money-back guarantee.

Shop Joy Organics CBD Oil Tincture


2. NuLeaf Naturals

Full-Spectrum CBD Oil

Nuleaf top ten CBD for entourage effect

It’s 100% organic, 100% local, and 100% recommended (at least by us). There are over 16,000 reviews for NuLeaf Naturals full-spectrum CBD oil, and nearly all are five-star reviews, where users praise NuLeaf’s customer service and the CBD oil’s possible efficiency in relieving joint pain. This high-grade hemp extract harbors 750mg of CBD per 15mL bottle and contains zero herbicides, GMOs, pesticides, or chemical fertilizers.

It’s one of the safest CBD formulas out there and, thus, is highly recommended for those with more severe ailments such as seizures. When your body is sensitive, the last thing you want to do is put anything artificial inside of it. With the ability for customers to purchase a single bottle or a pack of six, those who fall in love with the product can really stock up. It also should be noted that NuLeaf’s CBD potency is on the stronger side, with a much richer flavor than other products and more fast-acting effects.

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3. Elixinol

Daily Balance CBD Tincture

elixinol top 10 for epilepsy and seizure disorders

Elixinol is a CBD company that aims for complete transparency, totally organic products, and community building through giving back. The company’s full-spectrum CBD oil is free of harmful chemicals like Propylene Glycol (PG) and contains zero solvents. Using CO2 extraction methods, Elixinol’s hemp is grown both in the US and in Europe, with local hemp farms in Colorado. Their CBD tinctures have a base ingredient of coconut oil and come in both cinnamint and natural (unflavored).

Elixinol practices total transparency by providing batch numbers for each product as well as lab reports on its website. Elixinol is a company you can trust to stay natural and honest, but you can also use purchases made at Elixinol to give back. For every product sold, the company will donate 5% of that revenue to a non-profit of your choosing. Customers can choose from one of 6 already established options, such as the American Brain Tumor Association or Autism One, or can request another non-profit to donate to.

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4. Charlottes Web

CW Hemp Extract Oil Advanced

Charlotte’s Web was developed by Jesse and Joel Stanley of Colorado and is the company most referred to when one thinks of CBD oil for the potential treatment of seizures. They provide some of the highest quality oils in the industry. their flagship product, CW Hemp Extract Oil Advanced, contains 43 mg of CBD per serving and is packed with naturally occurring phytocannabinoids, terpenes, and flavonoids. Grown responsibly on US family farms and extracted using the CO2 method, it may be beneficial for promoting overall health and working as a neuroprotectant. the oil comes in mint chocolate or a rich, earthy, olive oil flavor.

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5. Populum

Full Spectrum Hemp CBD Oil 500 mg

Populum sources only organic Colorado-grown hemp to create their premium CBD products that contain no fillers or artificial ingredients. Using crossbred strains grown especially for their high CBD content, they have crafted a tincture that is potent and effective. All of their products have been thoroughly third-party tested, with a copy of the lab report included with your order so you always know exactly what you are getting.  The company offers a risk-free trial and excellent customer service. This formulation has a mild citrus flavor and comes in three concentrations.

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6.  Fab CBD

1200 mg Premium CBD Oil Drops

Crafted from only organic ingredients, Fab’s CBD drops are certified non-GMO, and their source hemp has been manufactured without the use of pesticides, herbicides, chemical fertilizers, or solvents. They contain pure CBD, a beneficial MCT carrier oil, and natural flavors. All of Fab’s products have been tested for potency and quality. A relative newcomer to the Cannabis industry, they provide excellent customer service and an easy-to-navigate website. These Premium CBD Drops come in three flavors: natural, citrus, and mint.

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7. Hemplucid

1500 mg Whole Plant Hemp Extract

Hemplucid’s oil has just two ingredients: CBD and MCT oil. MCT is a carrier oil that is rapidly digested so that it is metabolized easily by the body, and many studies have shown that MCT fats help to support brain health as well as healthy body composition. This product has a mild hemp flavor and can be conveniently taken under the tongue or even added to foods. Hemplucid’s oils are non-GMO, certified organic, and kosher. Their operations are some of the most transparent in the industry, with third-party lab results readily available onsite.

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8. Bluebird Botanicals

2000 mg Hemp Complete

Winner of the 2016 Cannabist Awards, Bluebird Botanicals provides some of the best customer care in the CBD industry. Their well designed and intuitive website is simple to navigate, but it’s their intense focus on providing others with a viable, natural health solution that sets them apart. They offer assistance programs for veterans, the disabled, and those on a low income. All of their high-quality CBD products are guaranteed to please, or your money back. Their 2000 mg hemp complete is GMO-free,  vegan, organic, and is infused with a blend of naturally-occurring terpenes for added potential therapeutic benefits

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9.  Medterra

CBD Tincture

Medterra is not your average CBD company.  They were established as a result of the hemp pilot program in Kentucky, so their entire process from seed to shelf is carefully monitored for quality.  This tincture is 99.6% pure CBD that is 100 percent THC free. It is non-GMO 100% organic and comes in strengths of 500mg, 1000mg, and 3000mg. It is safe, legal, affordable, and easy to use. Medterra utilizes clean and efficient CO2 extraction in the creation of their CBD products and provides third-party lab testing results right on site.

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10. CBDmd

1500 mg CBD Oil Tincture

At a cost of 5 cents per mg for their 3000mg CBD oil tincture, CBDmd offers a high-quality product that is one of the most affordable on the market. And there is no need to sacrifice quality either, as their products are crafted from 100 percent organic, domestically sourced hemp. Containing potentially beneficial terpenes, amino acids, and flavonoids, their full-spectrum tinctures are non-GMO, vegan, and gluten-free. In 2016, CBDmd won awards for the best flavor, best quality, and the reviewer’s choice award.

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What Is CBD?

CBD is short for Cannabidiol, a compound found in the Cannabis Sativa plant. Cannabis Sativa contains many such compounds, called cannabinoids,  but only two have been widely studied to date for their therapeutic properties—CBD and THC (tetrahydrocannabinol). You are probably already familiar with THC, the substance responsible for the psychoactive effects that take place when you smoke or ingest marijuana.

CBD is unique from THC in that it is non-intoxicating and will produce no euphoria, high, or discomfort. Instead, it has the potential to treat a broad range of physical and mental conditions. CBD acts as an adaptogen, working synergistically with the body’s own endocannabinoid system and and it may provide relief wherever it is needed. Because of these factors, it has become a popular homeopathic remedy that is gaining the attention of scientists and researchers worldwide.

What is the endocannabinoid system?

In the late 1980s, scientists were trying to find out how THC worked in the body. Their research revealed a previously undiscovered system that plays a vital role in maintaining optimum health. They aptly named it the endocannabinoid system (ECS).

This vast network of receptors located throughout the body outnumbers all the rest of our neuromodulatory receptors combined, including neurotransmitters! Animals possess this system as well.

The human body creates its own internal cannabinoids, which we call endocannabinoids. They help maintain the proper functioning of various biological systems by interacting with the corresponding receptors. These receptors are located throughout the central nervous system, the brain, lungs, kidneys, liver, eyes, and digestive tract. Moreover, because of the strategic placement of these cannabinoid receptors, an overdose of CBD is rendered impossible.

Amazingly, when CBD is introduced into the body, it fits perfectly into these receptors and may help restore or maintain homeostasis. This serves to stimulate the body’s cannabinoid production as well, giving it a little jumpstart.

While there is still much to learn about the human endocannabinoid system, we do know that two particular receptors, CB1 and CB2,  play a vital role in synergistically interacting with phytocannabinoids like CBD. These interactions have been shown to have possible healing effects on people with epilepsy and seizure disorders.

Some researchers believe that seizure disorders can be traced to an endocannabinoid deficiency. This would explain why using CBD seems to work so well at relieving these symptoms.

The Benefits of CBD in the Treatment of Seizure Disorders

In 2018 the FDA approved the use of CBD for the treatment of two rare and serious forms of epilepsy, Lennox-Gastaut syndrome, and Dravet syndrome. The long-awaited approval serves to reduce the stigma associated with medical cannabis and will improve the research climate of CBD overall.

There are many anti-epileptic drugs available to treat the condition, yet cases of intractable epilepsy continue to exist. One of the largest studies conducted to date included 162 patients who were treated with pure CBD oil for 12 weeks. The results showed that CBD worked as well as existing medications for epilepsy in these treatment-resistant sufferers.

While scientists still don’t understand precisely how CBD works in the treatment of epilepsy and other seizure disorders, it is believed that the anti-convulsive properties of CBD work on different targets in the brain. These targets include:

•glutamate receptor antagonists
•sodium ion channels
•calcium ion channels
•GATA system and receptor agonists

Side Effects

One of the most remarkable things about CBD is its lack of adverse side effects. CBD’s high safety profile makes it an attractive option for most people.  The mild reactions that are reported include diarrhea, tiredness, and changes in weight or appetite.

However, CBD has also been shown to increase the effectiveness of certain blood thinners, so patients who are already on medication for any serious health condition should check with their medical provider before taking CBD.

What about THC?

Many researchers believe that the entourage effect that takes place when CBD and THC are combined serves as an even better treatment for epilepsy. And indeed, it does seem that many people respond better to a CBD product that has a small percentage of THC in it as well. Most patients will have to experiment to find out the right option for them.

Because CBD is legal in almost every part of the country, it is easier to obtain, but in states where whole-plant cannabis is legal, a local dispensary or cannabis physician can help you formulate a ratio of CBD to THC if that is what is needed. Though the addition of THC is not necessary to reap the benefits of Cannabis, in places where it is easily obtainable, adding a small concentration of it to your CBD regimen may improve overall seizure activity.


These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

All content at Best Choice Reviews concerning CBD (Cannabidiol) or other health-related matters are for informational purposes only and are not to be considered as a substitute for medical advice, diagnosis, or treatment. If a reader has further questions about the use of these products, we encourage them to consult with a licensed physician or other qualified healthcare providers. The information included here is for informational purposes only and Best Choice Reviews is not responsible for the inappropriate use of these products.